Feb 13 2015

The Science behind Enobosarm

Published by under Chemicals

Enobosarm is the generic name of an investigational selective androgen receptor modulator. Also known as Ostarine, it was first developed for the purpose of increasing muscle mass and bone density. This is particularly helpful for those handicapped by debilitating diseases—it was a new alternative over those steroids which have benefits that cannot surmount the heap of undesirable side effects they simultaneously bring. Since it affects both bone and muscle, Ostarine is used for treating osteoporosis, osteopenia, muscle sarcopenia, cachexia in cancer patients, and even andropause. But what is the science behind Enobosarm?

Selective receptor modulators are drugs that affect tissue types differently—for instance, a selective receptor modulator may be beneficial for one tissue type while being an antagonist to another. As a selective androgen receptor, it has the same effects as other androgenic drugs like anabolic steroids—but more selective in terms of impact, as previously mentioned. The selectiveness in terms of effect—since the modulator discriminates according to tissue type—also allows it to be used in many more circumstances as compared to anabolic steroids, which have limited legitimate usage.

enobosarmThe androgens that are usually used—for instance, in case of male hormone replacement therapy—are injectable or in-skin delivery formulations. However, injectable forms are known to spike testosterone levels in blood, excessively increasing first and then leveling down drastically afterward. Skin delivery formulations, on the other hand, allow a more acceptable testosterone blood level profile. With selective androgen receptor modulators like Enobosarm, the goal is to customize tissue response. After oral ingestion, the selective androgen receptor modulator would elicit a response from target tissues in the same way these would respond to testosterone, without the risk of side effects for healthy, non-targeted tissues.

This goal, while already achieved at some level, has not been fully perfected. Selective androgen receptor modulators targeted at muscle or bone still cannot operate without creating androgenic effects on some tissues, like the prostate gland. However, even if selective androgen receptor modulators unavoidably create virilizing effects in high doses, they have been proven to be considerably selective in application for anabolic effects provided they are administered in low dosages. This is crucial especially if the modulators will be utilized to treat osteoporosis in women.

For example, Ostarine can be used to build and maintain lean muscle mass. Ostarine binds with the androgen receptor and then demonstrates osteo-anabolic and myo-anabolic activity. Once the androgen receptor is activated, gene expression is altered, thus increasing protein synthesis. This equates to more muscle mass. In this aspect, Ostarine works in a similar manner as steroids. The key difference, however, is that it does not foster the same growth effect on prostate and secondary sexual organs. Some of the most recent formulations of selective androgen receptor modulators almost exclusively have anabolic effects on muscle tissue.

The mechanics of the selectivity of Ostarine can also be described according to gender. For instance, when used in bone growth for males in cases of osteoporosis or osteopenia, the prostate and testes will be minimally affected, if at all. For females, selective androgen receptor modulators can be used for bone retention, and the stimulation of libido and other androgen-influenced sexual functions without the side effects of virilization—the development of male gender characteristics—increased cholesterol levels, and liver dysfunction, among others.

Furthermore, one of the great breakthroughs made by selective androgen receptor modulators like Enobosarm is that the molecules can now be administered orally. This is a substantial improvement over the anabolic steroid alternative. Most anabolic steroids are not active orally and are injectable. Those that are not orally active have a great tendency to cause liver damage, depending on the dosage.

Author Bio:

Enobosarm is the generic name of an investigational selective androgen receptor modulator. Also known as Ostarine, it was first developed for the purpose of increasing muscle mass and bone density.

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Feb 10 2015

Creative Edges to Enhance Custom Challenge Coins

Published by under Military

Custom challenge coins are tiny pieces of medallion with some organization emblem or slogan engraved in them. As a symbol of being part of the team, these become a possession people proudly collect, treasure and use. It is in the military that the use of these emblems was first introduced. There had been a practice in the military where they award some form of display material by affixing with the outfit of an individual so that any person who sees him can recognize his dignity level and authority level. In general, such insignias have the purpose of prestige signal. Men and women, who display some type of courage in battle or who have some outstanding attributes as compared to ordinary people, receive these prestige symbols.

 

Custom Challenge CoinsStone may be constructed to a beautiful artwork with the sparkle of creative imagination. The same goes for custom challenge coins too. A long time ago when they were launched in the midst of the military grounds, men and women would have barely imagined of the ingenuity that is integrated with these coins at present. These challenge coins have invariably been utilized as a present, award, symbol of respect, unit representation and so on. It always brings about joy to give something with a shade of creative thinking. It could be custom-made with wonderful creative edges and the present world offers a great deal of examples to show. The coins may be used as customized gifts and the creative edges included in it only enrich the beauty.

 

What are the different kinds of creative edges?

 

A great way to give a stylish look to the coins, the edges could be improved with some added creative effects. Customarily, these coins are circular in shape with plain edges. Nevertheless, various kinds of touches, including cross cut edge, flat edge, line edge, wired edge, and the like may be put into it. Over and above the logo and slogan embossed on the body of the custom challenge coins, their creative edges can also make an essential mark. Many of the most in-demand creative edges are enumerated below.

 

1. Cross Cut Edge

Crisscross designs and cut edges can be fashioned to the edge of the coins in order to provide a distinctive appearance. Several forms of cut edges could be integrated in with assorted designs.

 

2. Flat Edge

Flat edge is regarded as the most classic and commonly used among all other forms of creative edges. When the preference is an elegant and formal approach, people can choose this kind of edge.

 

3. Line Edge

Quite resembling the cut styles, line edge can also be incorporated with various designs: thick, thin, curvy and so on. A selection of lines can be utilized for these creative edges.

 

4. Rope Edge

Another one of the most widely used creative edge is the rope edge. This is ultimately well suited for metallic coins. There may be unique variations of strands utilized for making rope edges for the challenge coins.

 

There is a lot more of these designs for creating edges which they can use when making challenge coins. Every one of the creative edges mentioned above can be combined with various supplies used in designing. Essentially the most widely used are silver, gold, copper, metallic and many others.

 

Custom challenge coins already look wonderful, to begin with. With creative edges, the beauty of the coins is enriched. For instance, a challenge coin having a 3D image looks more desirable when designed with a crisscross or line edge. In addition, these creative edges do not just make the coins even more appealing, these also raise the monetary value of the coins.

 

By having beautifully designed edges, the coins may be displayed with a higher prominence. Creative imagination always catches the attention and captures the heart. Since its primary goal is to get to the heart, these creative edges enhance the feeling sense. Creative edges are also advantageous when it comes to marketing a business.

 

Author Bio:

Custom challenge coins are tiny pieces of medallion with some organization emblem or slogan engraved in them. As a symbol of being part of the team, these become a possession people proudly collect, treasure and use.

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Feb 09 2015

What are Discount Golf Clubs?

Published by under Sports

A golf club is the main tool to hit the golf ball to the hole. It has been around since the 15th century, originally carved out of wood by golf players and wood crafters. Plain wood materials, metals such as steel and aluminum were slowly incorporated for use on golf clubs. Today golf clubs are made out from various materials more than wood, leather and metal and are available in variants for right and left handed players. Golf clubs are even specially made for men and women.

Discount golf clubsDiscount golf clubs barely have any difference from typically priced golf clubs. In a golf set, there are a at least 14 golf clubs, each made for a specific shot and range so if you break one, you can’t simply think you can use the rest to replace your broken golf club but of course, golf clubs can be bought separately. A golf set, even discount golf club set would set you back at least US$200. While typically each golf club would fetch a 3-digit price, discount golf clubs are priced usually around US$60 up to US$200, depending on the brand and type of golf club. Discount golf clubs in the 3-digit range are usually bundled with a free shipping offer.

Before starting to pick discount golf clubs, first you need to know more about them and their parts.

Club

This is the end used to hit the golf ball. Each kind of golf club varies in the shape of the club and the length of the shaft. Clubs use one face to hit the ball but putters use both since they are symmetrical. A putter (a type of club) has legally two striking face with a loft not over 10 degrees. Golf club heads are normally made from alloys of aluminum (HST Aluminum) and zinc. An alloy means that it has been mixed with other metals to become more durable. Different kinds of steel like 431 stainless steel and 17-4ph stainless steel are used in professional iron and wood heads. High end golf heads use high performing wood and titanium and are preferred by professionals. Even discount golf clubs made from titanium will fetch a high price. Ti-Alloy is a titanium alloy material and is cheaper than pure titanium heads.

Beginner irons and woods include zinc, aluminum alloys and Ti-Alloy. More expensive golf clubs use titanium, 431 and 17-4ph stainless steel, maraging steel and tungsten insert.

Hosel

The hosel is the connection between the club and the shaft. It is lightweight to keep the center of gravity of the club fixed.

Shaft

The shaft makes up for the length of the club. It is tapered and is commonly made from steel and graphite (a carbon fiber composite). Graphite shafts weigh less than steel shafts. Each shaft is made with a specific kind of shaft flex or the amount the shaft can bend to deliver the force to the ball. The classifications of shaft flex are the following:

1. L/W-Flex: For ladies

2. A-Flex: Senior

3. I-Flex: Soft regular or intermediate

4. R-Flex: Regular

5. S-Flex: Stiff

6. X-Flex: Strong

The kind of shaft would depend on the head speed of the club, measured in mph or kph. Some companies offer flexes that fall between the categories above. The more flexible the shaft is, the higher the torque.

Grip

The grip is the end where the player holds onto. Leather wrap grips are still available but most golfers prefer grips that act as sleeves that they can simply slip unto the shaft. Grips can be bought separately. The grip’s diameter, texture and softness will depend on the golfer’s preference.

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Feb 02 2015

Why Buying a Home in Today’s Long island real estate Market is a Wise Financial Decision

Published by under Real Esate

Buying a home in the current Long island real estate market seems to be a difficult task. Currently, home inventories have fallen and some lenders are quite strict in screening wannabe homeowners. But despite these difficulties, buying a home might actually be a prudent financial decision especially for those who want to start their own families. Here are a few reasons why buying a home in Long Island will benefit you in the long term.

Mortgage rates are still low

Long island homes for saleThe average 30 year fixed mortgage rate in June 2013 is around 3.5 to 4.5 percent. While this figure seems to be a bit higher than those in the previous years, it is still comparatively better than the interest rate a few years ago. A 4 percent mortgage rate is way better than the 6 percent mortgage rate that prevailed a few years ago. With such low interest rates, there might be no better time to buy a home in the Long island real estate market than now.

If you buy a home 5 years from now, you might not be able to enjoy such low mortgage rates. Imagine the potential savings you may get from the current market condition.

Home prices are appreciating steadily

Home sales as well as prices have been increasing steadily for some time now. For instance, the median price of houses in Suffolk in May 2013 was around $315,000, four percent higher than the figures in May of the previous year. The trend is stable so when you buy a home now, its price will likely improve in the long term.

You don’t need to pay rents

One main benefit of owning your home is that you don’t have to pay rents just to stay and live inside a house or condominium. Renting will just take money away from your income without you owning the place. In addition, rents typically increase, basically taking a bigger slice of your paycheck. On the other hand, if you own your own home, your monthly amortization won’t likely increase.

You can save money on taxes

Buying a home now might save you some cash while at the same time giving you an opportunity to have your own piece of the American Dream. You can deduct the property taxes as well as the interest that you pay for your mortgage from your taxes.

Buying a home in today’s Long island real estate market could be quite helpful to your financial situation. By buying a home now, you can save some money on taxes and rent while at the same time having your own piece of the American Dream. Also, you can take advantage of the low interest rates, an awesome incentive that may not be there anymore once the Fed decides to end its stimulus program.

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Jan 28 2015

Why Printed Circuit Boards are Important?

Published by under Electronics

One of the most common parts of an electronic device that are not usually seen is the printed circuit board assembly (also known as the PCB assembly). This is used to connect the device’s different electronic components without the need for several wires. The electronic components are attached to a circuit board which is made of a semi-conductor material and has an electronic circuit engraved onto it. The electronic patterns of the circuit boards are made so that the electronic components these need will only connect and function when put in the right place. Printed circuit boards are also called as printed wiring cards or printed wiring boards.

There are many parts composing a PCB assembly. Once all these parts are assembled together, they would look like a single solid unit.

In order to make a printed circuit board, choosing the right materials is the initial step. The materials that will be used should be a semi-conductor or materials that are completely insulated against electricity. One of the most common materials used for printed circuit boards is fibreglass. Fibreglass is inexpensive to produce plus it is durable yet light in weight.

PCB assemblyThere are also some designers who are using different computer aided design (CAD) programs in order to produce different patterns for the printed circuit boards. These designs will be engraved or etched onto the PCB assembly. The computer aided design program used will aid the designer in getting a preview of the product first so the electronic circuits to be printed directly onto the board will not overlap with other electronic components. The holes needed on the circuit board will be punctured as well. This method is very helpful especially if the design to be made is a multilayer circuit board.

Copper is the usual material used as a conductor for most PCB assembly. During the time when the circuit board is still developing, manufacturers and designers pasted a copper foil at the bottom part of the circuit board in order to create a path for the circuit. For the modern printed circuit boards, the copper is etched directly on the board so that it will not fade or be disrupted when used.

There are a lot of ways to install electronic components into a printed circuit board. If the component is circular in shape and can fit into holes, it can be readily set into the circuit board through the plated holes. After the electronic component is set, it will be screwed or riveted to secure it in place. Soldering the electronic component is also used to provide a better contact between the electronic component and the circuit board. To ensure that the electronic component will be installed in place, the plated holes also have a copper ring around it.

There are also different ways on how to connect or place an electronic component into the printed circuit board. Through the use of the “Through Mount Technology”, the most common means of adding an electronic component into a circuit board, the holes are drilled directly into the circuit board and are marked with a copper ring (also known as annular ring). The component will be placed into the hole and will be soldered to secure in place.

The “Surface Mount Technology”, on the other hand, is used when the electronic component is stamped directly on the printed circuit board. This is commonly used for smaller electronic components such as the resistor. There is also no need to solder the electronic component in place anymore.

Due to the production of the printed circuit boards, it makes the production of the electronic devices cost-efficient, faster and easily accessible. It also allows manufacturers and engineers to create more useful and compact electronic devices that will make the lives of people easier.

Author Bio:

Pcb assembly capabilities are: SMT, Flip chip, thru hole, Flex circuit assembly, cable assemblies, Pb-Free assembly, and Wire harness assembly. We offer Full Turn-Key service for all our customers if needed as well as Partial turn-Key and Consignment orders.

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